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Although the basementmembrane is classically described as exclusively associatedwith epithelia, similar PAS-positive and silver-reactivesites can be demonstrated surrounding peripheral nerve sup-porting cells, adipocytes, and muscle cells (Fig. Functional impair-ment such as immobility including physical restraint use andthe use of indwelling bladder catheters greatly increases therisk of delirium and functional decline. Although Step 3 seldomasks specifically for the diagnosis, the management of constipation involvescorrecting the underlying cause.